There were some Crawlers, that were supposedly Too Tough to fight, had to Run from them.
Since Crawlers were on the ground, used higher places to avoid and attack 'em.
Attacking Giant Crawlers did nothing, if only had a launcher...
Grenades were useful at destroying Orbs, an Orb required one, or two grenades to destroy.
Greatly improved Defence through Genetics, combining them can produce New Abilities.